CREAM - Center for Regulatory and Environmental Analytical Metabolomics
The Department of Chemistry in partnership with the James Graham Brown Cancer Center at the University of Louisville was awarded a large NSF/EPSCoR infrastructure grant to establish a program for Regulatory, Environmental, Analytical Metabolomics. This program has developed a cutting-edge methodologies and approaches for the emerging metabolomic and system biochemical research. This area of research has the promise of revolutionizing biological research in the 21st century for the ability to resolve biological complexity. Thus, metabolomic development will find applications in a broad array of pressing societal problems ranging from human health, biotechnology, to environmental pollution and ecosystem health.
The expertise of Faculty associated with CREAM spans all aspects of Metabolomics. We represent several Departments on both the Belknap and Health Sciences Campuses of the University of Louisville.
Shumaker Research Building on the University of Louisville campus where CREAM Mass Spectrometry instrumentation is housed.
Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells.
Le A, Lane AN, Hamaker M, Bose S, Gouw A, Barbi J, Tsukamoto T, Rojas CJ, Slusher BS, Zhang H, Zimmerman LJ, Liebler DC, Slebos RJ, Lorkiewicz PK, Higashi RM, Fan TW, Dang CV.
Cell Metab. 2012 Jan 4;15(1):110-21.
CREAM article selected in the Cancer in Chemistry Research Highlights.
The metabolic profile of tumors depends on both the responsible genetic lesion and tissue type.
Yuneva MO, Fan TW, Allen TD, Higashi RM, Ferraris DV, Tsukamoto T, Matés JM, Alonso FJ, Wang C, Seo Y, Chen X, Bishop JM.
Cell Metab. 2012 Feb 8;15(2):157-70.
CREAM article is most downloaded Pharmacology and Therapeutics article in the last 90 days from SciVerse ScienceDirect (March 2012).
Stable isotope-resolved metabolomics and applications for drug development.
Fan TW, Lorkiewicz PK, Sellers K, Moseley HN, Higashi RM, Lane AN.
Pharmacol Ther. 2012 Mar;133(3):366-91.
CREAM welcomes inquiries from interested scientists who may wish to learn tracer technologies in metabolomics.
Contact CREAM Director Dr. Teresa Fan via email or voice for more information.