Areas of Research Interest:

My research interest is the mathematical modeling of biological systems. I am especially concerned with profiling of cancer-specific metabolic changes in terms of metabolic flux analysis, isotopomer analysis, and model-driven systems biology. Since isotopomers formed from substrates labeled with stable isotopes contain rich information about metabolism, they can be utilized to quantitate intracellular metabolic pathway activities. Further to this, I am very much interested in in silico identification of atomic level biomarkers for lung cancer that are easily detectable using NMR and/or MS. Such computer-aided quantitative metabolic profiling will afford a giant step towards personalized diagnostics and will help us to understand cancer biology in the sense of systems biology through combination with other ‘omics’ tools.

Recent Publications.

Yang, T. H., Frick, O., Heinzle, E., 2008. Hybrid Optimization for ¹³C Metabolic Flux Analysis Using Systems Parametrized by Compactification. BMC: Systems Biology. accepted.

Yang T.H., 2007. Metabolic Flux Analysis. in: Handbook of Metabolomics (Eds: T. W-M. Fan, A.N. Lane, R.M. Higashi). In the series Methods in Pharmacology and Toxicology (Series editor: J. Kang), Humana Press, Totowa, NJ, in press.

Heinzle, E., Yang T.H., Deshpande, R., 2007. Analysis and Design of Metabolic Networks - Experiments and Computer Simulation.17th European Symposium on Computer Aided Process engineering, 24. Plesu, V., Agachi, P. S. (Eds.). Elsevier, Amsterdam.

Yang, T. H., Wittmann, C., Heinzle, E., 2006. Respirometric ¹³C Flux Analysis. Part I: Design, Construction and Validation of a Novel Multiple Reactor System Using On-line Membrane-Inlet Mass Spectrometry. Metabolic Engineering. 8, 417-431.

Yang, T. H., Wittmann, C., Heinzle, E., 2006. Respirometric ¹³C Flux Analysis. Part II: In vivo Flux Estimation of Lysine-producing Corynebacterium glutamicum. Metabolic Engineering. 8, 432-446.

Yang, T. H., Heinzle, E., Wittmann, C., 2005. Theoretical Aspects of ¹³C Metabolic Flux Analysis with Sole Quantification of Carbon Dioxide Labeling. Computational Biologly and Chemistry. 29. 121-133.

Yang, T. H., Wittmann, C., Heinzle, E., 2004. Metabolic Network Simulation Using Logical Loop Algorithm and Jacobian Matrix. Metabolic Engineering. 6, 256-267.

Yang, T. H., Wittmann, C., Heinzle, E., 2004. Membrane Inlet Mass Spectrometry for the On-Line Measurement of Metabolic Fluxes in the Case of Lysine-Production by Corynebacterium glutamicum. Engineering in Life Sciences. 4, 252-257.

Yang, T. H., Wittmann, C., Heinzle, E., 2003. Dynamic Calibration and Dissolved Gas Analysis Using Membrane Inlet Mass Spectrometry for the Quantification of Cell Respiration. Rapid Communications in Mass Spectrometry. 17, 2721-2731.

Yang, T. H., Wittmann, C., Heinzle, E., 2003. Membraneinlass-Massenspektrometrie zur prozessnahen metabolischen Flussanalyse am Beispiel der Lysin-Produktion von Corynebacterium glutamicum. Chemie Ingenieur Technik. 75, 1359-1364.

Wittmann, C., Yang, T. H., Kochems, I., Heinzle, E., 2001. Dynamic Respiratory Measurements with Corynebacterium glutamicum Using Membrane Mass Spectrometry. J. of Microbiology and Biotechnology. 11, 40-49.