Systems Physiology & Phenotyping Core
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About Us
The Systems Physiology & Phenotyping Core provides in vivo animal surgeries and cardiovascular models with ultrasound imaging, invasive hemodynamics, electrophysiology, radiotelemetry, and metabolic phenotyping.
The Systems Physiology & Phenotyping Core is a core component of the Center for Cardiometabolic Science.
Services
- Surgical animal models: myocardial ischemia with or without reperfusion, transverse aortic constriction, apical resection, intracardiac /intraventricular injections (ultrasound-guided/open-chest), arterial and venous catheterization, splenic transplantation, vascular anastomosis, radiotelemetry implantation, and others
- Consultation on new animal model development and training on small animal surgeries
- Ultrasound on small animals
- Invasive hemodynamics: Pressure-Volume Loops
- Programmed Electrical Stimulation
Equipment & Instruments
- VisualSonics Vevo F2 and Vevo 3100 preclinical ultrasound systems
- Surgical stations with dissecting microscope, heating source and ECG monitoring
- Pressure-volume loop: Millar conductance MPVS system, and Transonic Sciences ADV 500 conductance/admittance system
- Pressure monitoring system: Millar SPR-1000 (1F, 0.33mm) and Opsens Optical fiber M200 (0.6F, 0.20mm, MRI capable)
- Programmed Electrical Stimulation: STG-3004 (4 channels) and STG-3008 (8 channels) system, equipped with octopolar catheter EPR-800 or EPR-801(with lumen for test agent delivery)
- Data Sciences International (DSI) small animal telemetry system
Serving
- UofL Researchers
- External-Academic
- External-Industry
Core Acknowledgement
Researchers are strongly encouraged to acknowledge the use of this core facility in publications and presentations. Doing so documents the role of shared infrastructure in advancing UofL research and supports the core’s continued operation and growth.
Consider using the suggested language below when making acknowledgements in your work:
This [publication, project, or research] was made possible, in part, by the Center for Cardoiometabolic Science Systems Physiology and Phenotyping Core at the University of Louisville.
Core Personnel
Scientific Faculty Directors
Yibing Nong
Director, Systems Physiology & Phenotyping Core
Kenneth Brittian
Lab Manager